Pore spacing gradient can direct endothelial cell migration in microphysiological systems

Abstract

Porous membranes are one of the main components of microphysiological systems. They can compartmentalize different cell types and establish physiologically relevant cell-cell communication between co-cultured cells. We previously showed that porous membranes' characteristics can modulate cell-substrate interactions and guide cell responses. Pore spacing is a major characteristic that can control cell-substrate interaction since it provides the required area for the development of ECM and adhesive components.