Pore-covered thermoresponsive membranes for repeated on-demand drug release

Abstract

Reversible on/off-switching of bovine serum albumin (BSA) permeation through a thermoresponsive composite membrane with negligible permeation in the off-state is demonstrated. UV-photografting of poly( N-isopropylacrylamide) onto a poly(ethylene terephthalate) microfiltration membrane results in a hydrogel graft layer on the irradiated side of the membrane only. The amount of hydrogel grafted onto the membrane can be controlled by the amount of crosslinker. Above the lower critical solution temperature (LCST) of the hydrogel (on-state), the shrunken state of the graft layer appears to only partially cover the membrane, allowing BSA permeation through the uncovered pores. Provided the grafting degree is high enough, the swollen hydrogel covers the membrane completely below the LCST (off-state), thus preventing BSA permeation. The on-demand release mechanism proposed here is based on switching the membrane surface coverage rather than previously reported switches based on effective pore size or hydrogel mesh size. The main advantage of our mechanism is that higher fluxes can be achieved in the on-state, since permeation is not limited by pore-narrowing.