Population-Based Mapping of Polygenic Risk for Schizophrenia on the Human Brain: New Opportunities to Capture the Dimensional Aspects of Severe Mental Disorders

Abstract

SEE CORRESPONDING ARTICLE ON PAGE 536 Impact of Polygenic Risk for Schizophrenia on Cortical Structure in UK BiobankBiological PsychiatryVol. 86Issue 7PreviewSchizophrenia is a neurodevelopmental disorder with many genetic variants of individually small effect contributing to phenotypic variation. Lower cortical thickness (CT), surface area, and cortical volume have been demonstrated in people with schizophrenia. Furthermore, a range of obstetric complications (e.g., lower birth weight) are consistently associated with an increased risk for schizophrenia. We investigated whether a high polygenic risk score for schizophrenia (PGRS-SCZ) is associated with CT, surface area, and cortical volume in UK Biobank, a population-based sample, and tested for interactions with birth weight. Full-Text PDF