Abstract
A multiple peak approach was used to evaluate the effect of age, total bodyweight, dose, gender and co-medication on the population estimates of carbamazepine relative clearance. Routine clinical pharmacokinetic data (n = 689) were collected from 317 patients receiving carbamazepine. The data were analysed according to a simple steady-state pharmacokinetic model with the use of NONMEM, a computer program designed for population pharmacokinetic analysis that allows pooling of data. NONMEM estimates indicated that the rate of carbamazepine clearance decreased nonlinearly with increasing total body weight in the maturation process, and increased nonlinearly with increasing daily dose (mg/kg) of carbamazepine. Concomitant administration of carbamazepine and other antiepileptic drugs showed an increase in carbamazepine clearance. These estimates were similar to those detected in previous studies.
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