Population Risk of Ischemic Heart Disease Depending on the Volume of Alcohol Consumption by the Population (ЭССЕ-РФ Study in the Kemerovo Region)

Abstract

to assess relationship between the prevalence of cardiovascular risk factors and associated population risk of ischemic heart disease (IHD) alcohol consumption in the Siberian region (Kemerovo Region). This work was carried out within the framework of a multicenter epidemiological study "Epidemiology of CardioVascular Diseases in the regions of the Russian Federation" (ЭССЕ-РФ in the Kemerovo region) in 2013. In the final form, the sample size was 1628 individuals aged 25-64 years. We analyzed data on frequency, volume, and type of consumed alcoholic beverages, as well as on the presence of a number of risk factors of cardiovascular diseases and IHD. Alcohol consumption was estimated by the original method, volume of alcohol consumed in a year was categorized as absent (non-drinkers), moderate, medium, and strong. The calculation of the population risk of IHD was carried out according to the author's methodology, taking into account the prevalence of risk factors and their contribution to the development of IHD. Prevalence of several risk factors among non-drinkers was significantly different (p<0.05) compared with drinkers with varying degrees of alcohol consumption. In men, there were differences in low physical activity, hypertriglyceridemia, excess weight, education, in women - in anxiety, low physical activity, hypertriglyceridemia, educational qualifications, smoking. In nondrinking men, the additional risk of IHD associated with risk factors was slightly reduced (-1.1 %). In groups of moderate, moderate, and strong alcohol consumption, risk of IHD was higher than the population risk by 2.2 %, 0.7 % and 6.5 %, respectively. In non-drinking women high burden of risk factors accounted for additional risk of IHD (4.5 %). In women with moderate and medium alcohol consumption the risk of IHD was 2.5 and 1.9 %, respectively, lower compared with population risk. Abuse of alcohol in women caused significant increase in the burden of risk factors and, accordingly, was associated with high additional risk of IHD (18.7 %). Predominantly linear in men and J-shaped in women relationship between prevalence of risk factors and volume of alcohol consumption accounted for analogous tendencies in population IHD risk. Specific for men is close to linear dependence of additional IHD risk on population IHD risk with insignificant variability in non-drinkers, moderate and medial consumers, and with significant growth in alcohol abusers. Women have a J-shaped relationship: in extreme categories (non-drinkiers and alcohol abusers), the risk of IHD is higher than the population risk, while in the middle categories (moderate and medial consumers) it is lower than the population risk.