Abstract
Ethanamizuril is a new triazine compound that shows potential for application in novel anticoccidial treatment. In this study, a pharmacokinetic model of ethanamizuril was established on the basis of the blood concentration of 81 experimental animals. The final model showed that ethanamizuril was distributed as a two-compartment model with first-order absorption after oral administration in chickens. Its clearance rate and volumn of centralcompartment distribution (Vc ) were affected by age and body weight, and volumn of centralcompartment distribution (Vc ) and volume of peripheralcompartment distribution(Vp ) were influenced by weight and infection. External verification revealed that the model had good prediction accuracy and stability.
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