Abstract
BackgroundMild cognitive impairment (MCI) is the intermediate stage of the cognitive changes between normal aging and dementia. KLOTH is an age-related gene that may contribute to the risk of MCI. The aim of our study was to explore the association between KLOTHO promoter methylation and MCI in Xinjiang Uygur and Han populations.MethodsDNA methylation assay was performed using the bisulphite pyrosequencing technology among 96 Uygur (48 MCI and 48 controls) and 96 Han (48 MCI and 48 controls) Chinese individuals from Xinjiang province of China.ResultsWe found significant association between KLOTHO promoter methylation and MCI in the Han Chinese (CpG1: p = 3.77E-06; CpG2: p = 1.91E-07; CpG3: p = 5.83E-07; CpG4: p = 2.23E-05; CpG5: p = 3.03E-06) but not in the Uygur Chinese. Higher KLOTHO promoter methylation levels were found in Han MCI patients than Uygur MCI patients for all the five CpGs (adjusted p values by age < 0.02).ConclusionOur results showed that KLOTHO promoter hypermethylation contributed to the MCI risk in Xinjiang Han Chinese but not in Xinjiang Uygur Chinese. The population difference of KLOTHO methylation in the risk of MCI required further investigation in the future.
Highlights
Mild cognitive impairment (MCI) refers to the intermediate stage of the cognitive changes between normal aging and dementia [1]
We found significant association between KLOTHO promoter methylation and MCI in the Han Chinese (CpG1: p = 3.77E-06; CpG2: p = 1.91E-07; CpG3: p = 5.83E-07; CpG4: p = 2.23E-05; CpG5: p = 3.03E-06) but not in the Uygur Chinese
Higher KLOTHO promoter methylation levels were found in Han MCI patients than Uygur MCI patients for all the five CpGs
Summary
Mild cognitive impairment (MCI) refers to the intermediate stage of the cognitive changes between normal aging and dementia [1]. Individuals with MCI showed cognitive impairment greater than expected for their age and education, but their mental functions are relative complete and do not reach the criteria for dementia. About 10–15% of MCI persons develop into dementia (mostly Alzheimer’s disease, AD) per year, in constrast of 1–2% AD incidence in the general population per year [2]. The incidence of MCI ranges from 1% to 6% per year, while the prevalence ranges from 3% to 22% per year [3, 4] in the Western countries. Mild cognitive impairment (MCI) is the intermediate stage of the cognitive changes between normal aging and dementia. The aim of our study was to explore the association between KLOTHO promoter methylation and MCI in Xinjiang Uygur and Han populations
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