Abstract
TPS 642: Environmental justice and impacts, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM Background/Aim: Cancer is a major cause of illness in France, with 380,000 new cases estimated in 2015. An important part of them is potentially avoidable through modification of various lifestyle and environmental risk factors. We aim to present the estimation of the cancer burden in adults attributable to exposure to outdoor air pollution and environmental chemicals in France in 2015. Methods: The proportion of cancers that would not have occurred if exposure to avoidable risk factors had been at a safe level can be evaluated by estimating “population attributable fractions” (PAF). Three environmental risk factors were studied: fine particulate air pollution (PM2.5), arsenic in drinking water and indoor benzene. We obtained the following data (and source): annual PM2.5 mean concentration (the Gazel-Air model -a nationwide air quality model), mean arsenic concentration in drinking water (the Sise-Eaux database), and the mean concentration of indoor benzene (the French Observatory of the Indoor Air Quality). Cancer incidence data were obtained from the French network of cancer registries (FRANCIM). Results: In 2015, about 1,500 lung cancer cases (PAF=3.6%) could be attributed to exposure to high air PM2.5 level in France. Depending on the risk model used, the PAF and total number of lung cancer cases associated with PM2.5 exposure ranged from 1,0% (416) to 26,5% (10,733 cases). Estimation PAF for chemical agents was challenging due to lack of representative exposure data and robust risk estimates in the general population. Our estimates on the contribution of arsenic in drinking water and indoor benzene on cancer in France seems to represent only a negligible PAF. Conclusions: Policy action to reduce PM2.5 concentration in France could potentially reduce a portion of lung cancer incidence. Improved surveillance and measurement of environmental chemicals and epidemiological studies to quantify populational risks are needed.
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