POPs are associated with left ventricular systolic and diastolic dysfunction

Abstract

Purpose: Major risk factors for congestive heart failure (CHF) are myocardial infarction, hypertension, diabetes, atrial fibrillation, smoking, left ventricular hypertrophy (LVH) and obesity. However, since these risk factors only explain a part of the risk of CHF, we investigated if persistent organic pollutants (POPs) might also play a role.Materials and methods: In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), left ventricular ejection fraction, (EF), E/A-ratio and isovolumic relaxation time (IVRT), were determined by echocardiography and 21 POPs were measured by high-resolution chromatography coupled to high resolution mass spectrometry (HRGC/HRMS) in 998 subjects all aged 70 years.Results: In this cross-sectional analysis, high levels of several of the polychlorinated biphenyls (PCB congeners 99, 118, 105, 138, 153, and 180) and octachlorodibenzo-p-dioxin (OCDD) were significantly related to a decreased EF. Some POPs were also related to a decreased E/A-ratio (PCBs 206 and 209). All the results were adjusted for gender, hypertension, diabetes, smoking, LVH and BMI, and subjects with myocardial infarction or atrial fibrillation were excluded from the analysis.Conclusion: Circulating levels of POPs were related to impairments in both left ventricular systolic and diastolic function independently of major congestive heart failure risk factors, suggesting a possible role of POPs in heart failure.