Poorly Documented Association of PPI Usage with Osteoporosis: A Review

Zubair Ahmed

doi:10.34297/ajbsr.2019.03.000634

Abstract

Proton pump inhibitors are an effective class of pharmacotherapeutic drugs used to reduce stomach acid secretion and drug of choice for GERD, published literature suggested relatively less side effects and high efficacy but some recent studies have suggested that chronic PPIs usage leads to negative calcium balance with decreased absorption due to acid suppression and parathyroid hyperplasia as the plausible explanation for this less documented side effect of this widely used class of drugs increasing the risk for osteoporosis and resultant bone fractures. But no groundbreaking research has been published on interaction between PPIs and calcium homeostasis and must be taken up by researchers since the sheer prevalence of using PPIs further enhances the importance to completely understand the underlying mechanism and complex biochemical interactions and possible comorbidities with chronic usage.

Highlights

Introduction & BackgroundProton pump inhibitors have been extensively used by the general population since their introduction in late 1980s because of their high efficacy in acid related conditions and relatively less observed side effects [1]
Proton pump inhibitors are a group of drugs which reduce stomach acid secretion and are most effective class of acid secretion inhibitors [2]
PPIs are used as drug of choice in gastro esophageal reflux (GERD) in which lower esophageal sphincter is affected resulting in the backflow of acidic secretions of stomach causing heart burn and indigestion

Summary

Introduction

Introduction & BackgroundProton pump inhibitors have been extensively used by the general population since their introduction in late 1980s because of their high efficacy in acid related conditions and relatively less observed side effects [1]. Proton pump inhibitors have been extensively used by the general population since their introduction in late 1980s because of their high efficacy in acid related conditions and relatively less observed side effects [1]. Proton pump inhibitors are a group of drugs which reduce stomach acid secretion and are most effective class of acid secretion inhibitors [2].

Results

Conclusion