Abstract
Abstract Background: Endometrioid carcinoma and undifferentiated carcinoma in the ovary have not been reported together or in the same patient. Case: The case of a young woman who developed undifferentiated carcinoma ovary within 3 months of contralateral adnexectomy for well-differentiated endometrioid carcinoma stage I is presented. The probable etiopathogenesis and management are discussed. Total hysterectomy, right adnexectomy, and infracolic omentectomy with peritoneal sampling were performed. There was no grossly apparent residual disease and histology revealed a poorly differentiated ovarian adenocarcinoma and metastatic implants on the uterus and omentum. Combination chemotherapy was given. Results: The patient was disease free after 6 months. Conclusions: Both kinds of epithelial malignancies arose independently. A possible molecular mechanism could be operating at the genetic level to predispose women with low-grade epithelial tumors of low malignant potential to develop other epithelial tumors ...
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