Abstract
Periodic limb movements in sleep (PLMS) are more common in ESRD and HD patients than in the general population. We previously reported that PLMS in HD may he a predictor of mortality. We studied 50 HD patients by in center polysomnography to determine whether size (BMI) or serologic profile including nutritional factors correlated with PLMS. Using Pearson Product-Moment Correlations, both serum creatinine (r=−0.32, p < 0.03) and albumin (r=−0.41, p < 0.006) correlated negatively and significantly with PLMSI. Lower BMI also had a negative, hut nonsignificant correlation (r=−0.24, p < 0.07 ns) with PLMSI. Serum albumin was significantly different (3.48 vs. 3.88, p 6 PLMS/hr. of sleep, mean 67.2) vs. those with low PLMSI (<6 per hour of sleep, mean 0.9/hr. of sleep). Serum K + levels were alsov significantly lower in the high PLMSI group (5.0 vs. 5.6 mEq/L, p < 0.01). These results suggest that high PLMSI may be secondary to or associated with poor nutrition and may thus be an indirect marker of poor nutritional status in HD patients. This nutritional profile association may clarify the correlation of PLMS in predicting mortality in ESRD patients.
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