Poor muscle health and low preoperative ODI are independent predictors for slower achievement of MCID after minimally invasive decompression

Abstract

Although some previous studies have analyzed predictors of non-improvement, most of these have focused on demographic and clinical variables and have not accounted for radiological predictors. In addition, while several studies have examined the degree of improvement after decompression, there is less data on the rate of improvement. To identify the risk factors and predictors (both radiological and non-radiological) for slower as well as non-achievement of minimal clinically important difference (MCID) after minimally invasive decompression. Retrospective cohort PATIENT SAMPLE: Patients who underwent minimally invasive decompression for degenerative lumbar spine conditions and had a minimum of 1-year follow-up were included. Patients with preoperative Oswestry Disability Index (ODI) <20 were excluded. MCID achievement in ODI (cut off 12.8). Patients were stratified into two groups (achieved MCID, did not achieve MCID) at two timepoints (early ≤3 months, late ≥6 months). Non-radiological (age, gender, BMI, comorbidities, anxiety, depression, number of levels operated, preoperative ODI, preoperative back pain) and radiological (MRI - Schizas grading for stenosis, dural sac cross-sectional area, Pfirrmann grading for disc degeneration, psoas cross-sectional area and Goutallier grading, facet cyst/effusion; X-ray - spondylolisthesis, lumbar lordosis, spinopelvic parameters) variables were assessed with comparative analysis to identify risk factors and with multiple regression models to identify predictors for slower achievement of MCID (MCID not achieved by ≤3 months) and non-achievement of MCID (MCID not achieved at ≥6 months). 338 patients were included. At ≤3 months, patients who did not achieve MCID had significantly lower preoperative ODI (40.1 vs. 48.1, p<0.001) and worse psoas Goutallier grading (p=0.048). At ≥6 months, patients who did not achieve MCID had significantly lower preoperative ODI (38 vs. 47.5, p<0.001), higher age (68 vs. 63 years, p=0.007), worse average L1-S1 Pfirrmann grading (3.5 vs. 3.2, p=0.035), and higher rate of pre-existing spondylolisthesis at the operated level (p=0.047). When these and other probable risk factors were put into a regression model, low preoperative ODI (p=0.002) and poor Goutallier grading (p=0.042) at the early timepoint and low preoperative ODI (p<0.001) at the late timepoint came out as independent predictors for MCID non-achievement. After minimally invasive decompression, low preoperative ODI and poor muscle health are risk factors and predictors for slower achievement of MCID. For non-achievement of MCID, low preoperative ODI, higher age, greater disc degeneration, and spondylolisthesis are risk factors and low preoperative ODI is the only independent predictor.