Poor glycemic control in type-2 diabetic patients infected with hepatitis B: A retrospective propensity-matched study.

Abstract

Hepatitis B virus (HBV)infection and type-2 diabetesmellitus(T2DM)affect millions of individuals worldwide, whereas their interplay remains largely unclear. Here, we analyzed a large cohort of 330 HBV-infectedinpatients with T2DM (so-called HBV + T2DM patients) and 330 T2DM inpatients without HBV infection (T2DMpatients). Poor glycemic control was defined by glycated hemoglobin (HbA1c) ≥ 7%. Among 330 HBV + T2DM patients, 252 (76%) aged ≥ 50 years, 223 (68%) were males, 205 (62%) experienced poor glycemic control. The propensity-score matching approach was applied to match patient age, gender, comorbidities, and antidiabetic treatment between T2DM + HBV and T2DM patients. Compared with T2DM patients, HBV + T2DM patients had poorer glycemic control, longer hospitalization length, and higher alanine aminotransferase (p < 0.05). HBV + T2DM patients with HBV DNA ≥ 100 IU/mLor HBsAg ≥ 0.05 IU/mLhad worse HbA1c control than T2DM patients without HBV infection (p < 0.05). HBV + T2DM patients who received no anti-HBVtherapy had worse HbA1c control than HBV + T2DM patients receiving anti-HBVtherapy (p < 0.05). Both insulin and anti-HBVtherapy were significant factors associated with glycemic control in HBV + T2DM patients. Overall, HBV + T2DM patients exhibited poorer glycemic control than T2DM patients, but their clinical outcomes were likely improved by insulin plus anti-HBVtreatment. Early management of HBV infection likely contributes to better clinical outcomes in HBV-infectedpatients with T2DM.