Poor efficacy of albendazole for the treatment of human taeniasis

Abstract

In order to evaluate the efficacy of albendazole for the treatment of taeniasis, regimens of 400 mg × 1 day, 800 mg × 1 day, 800 mg × 2 days, 800 mg × 3 days, 1200 mg × 2 days, and 1200 mg × 3 days were compared. Of 66 cases treated and investigated 7–14 days after treatment, 52 were still expelling proglottids. Three months post-treatment, these cases were re-treated with atabrine at 1.2 g per case for males and 1.0 g per case for females. Fifty-seven patients expelled worms or parts of tapeworms. The nine negatives may represent the number cured by the treatment with albendazole. The cure rates with albendazole for various regimens were up to 50% for 800 mg × 3 days, 1200 mg × 2 days or 1200 mg × 3 days, 14.3% for 800 mg × 2 days, and 0% for 400 mg × 1 day or 800 mg × 1 day. This study shows that albendazole is not very effective in the treatment for taeniasis.