Abstract
BackgroundThe study aims at scientifically investigating the genetic effect of four polymorphisms (rs7975232, rs1544410, rs2228570, and rs731236) within the human Vitamin D Receptor (VDR) gene on the odds of psoriasis through an updated meta-analysis.MethodsWe searched eight databases and screened the studies for pooling. Finally, a total of eighteen eligible case-control studies were included. BH (Benjamini & Hochberg) adjusted P-values of association (Passociation) and odd ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated under the allele, homozygote, heterozygote, dominant, recessive, and carrier models.ResultsCompared with the negative controls, no statistically significant difference in the odds of psoriasis was detected for the cases under any genetic models (BH adjusted Passociation > 0.05). We also performed subgroup meta-analyses by the source of controls, ethnicity, country, Hardy-Weinberg equilibrium, and genotyping method. Similar results were observed in most subgroup meta-analyses (BH adjusted Passociation > 0.05). Besides, data of Begg’s and Egger’s tests excluded the significant publication bias; while the sensitivity analysis data further indicated the statistical reliability of our pooling results.ConclusionThe currently available data fails to support a robust association between VDR rs7975232, rs1544410, rs2228570 and rs731236 polymorphisms and psoriasis susceptibility, which still required the support of more case-control studies.
Highlights
The study aims at scientifically investigating the genetic effect of four polymorphisms within the human Vitamin D Receptor (VDR) gene on the odds of psoriasis through an updated meta-analysis
The currently available data fails to support a robust association between VDR rs7975232, rs1544410, rs2228570 and rs731236 polymorphisms and psoriasis susceptibility, which still required the support of more case-control studies
Referring to the HuGENetTM HuGE Review Handbook, version 1.0, we retrieved the relevant publications from eight online databases, including PubMed, Web of Science (WOS), Excerpta Medica Database (EMBASE), China National Knowledge Infrastructure (CNKI), WANFANG, OVID, Scopus and Cochrane, up to August 18, 2019, without any restrictions regarding geographical, language or publication time
Summary
The study aims at scientifically investigating the genetic effect of four polymorphisms (rs7975232, rs1544410, rs2228570, and rs731236) within the human Vitamin D Receptor (VDR) gene on the odds of psoriasis through an updated meta-analysis. The human VDR gene is mapped on chromosome 12 and contains four common polymorphisms, namely rs7975232 A/C in intron eight (ApaI) rs1544410 G/A in intron eight (BsmI), rs2228570 T/. VDR rs7975232, rs1544410, rs2228570, and rs731236 polymorphisms in the susceptibility to psoriasis disease. Genetic factors are potentially linked to the occurrence or pathogenesis of psoriasis [11, 12]. We observed the open questions of the association between the VDR polymorphisms and psoriasis susceptibility among different populations
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