Abstract
BackgroundThe present meta-analysis examined the diagnostic accuracy of T2 Candida for candidiasis.MethodsThe literature databases, such as PubMed, Embase, DVIO, Cochrane library, Web of Science, and CNKI, were searched on T2 Candida detection.ResultsA total of 8 articles, comprising of 2717 research subjects, were included in the study. The pooled sensitivity and specificity were 0.91 (95% confidence interval (CI): 0.88–0.94) and 0.94 95% CI: 0.93–0.95), respectively. The pooled positive likelihood ratio and negative likelihood ratio was 10.16 (95% CI: 2.75–37.50) and 0.08 (95% CI: 0.02–0.35), respectively. The combined diagnostic odds ratio is 133.65 95% CI: 17.21–1037.73), and the AUC of SROC is 0.9702 [(SE = 0.0235), Q* = 0.9201(SE = 0.0381)].ConclusionsThe current evidence supported that T2 Candida has high accuracy and sensitivity and is of major clinical significance in the diagnosis of Candida infection.
Highlights
The present meta-analysis examined the diagnostic accuracy of T2 Candida for candidiasis
The pooled sensitivity and specificity were 0.91 (95% confidence interval (CI): 0.88–0.94) and 0.94 95% Confidence interval (CI): 0.93–0.95), respectively
The combined diagnostic odds ratio is 133.65 95% CI: 17.21–1037.73), and the Area under curve (AUC) of summary receiver operating characteristic (SROC) is 0.9702 [(SE = 0.0235), Q* = 0.9201(SE = 0.0381)]
Summary
The present meta-analysis examined the diagnostic accuracy of T2 Candida for candidiasis. The hospital-acquired candidiasis (candidemia and other forms of invasive candidiasis) is a lifethreatening disease in patients with low immune function and severe illness [1, 2] It is the fourth leading cause of nosocomial infections in the USA. Despite the use of several antifungal agents, candidiasis is generally considered as a disease associated with medical advances and a leading cause of morbidity and mortality in the healthcare environment. This phenomenon might be attributed to the difficulty in diagnosing candidiasis and challenges in administering earlier and adequate antifungal therapy [5]
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