PON1 Inter-individual Enzymatic activity variation as a predictor of OPC toxicity in agricultural workers presented to PCCASU, Egypt

Abstract

Organophosphate compounds result in numerous toxicities because of their widespread usage and easy accessibility especially in the developing world’s agricultural communities. PON1 activity towards OPCs shows inter individual variations. Isoforms of the enzyme differing in their PON1 activity result from amino acid substitutions at positions 192 which is glutamine (Q) to arginine (R) and at 55 which is leucine (L) to methionine (M) thus rendering the identifi cation of individuals’ PON1 all enzymes of value in treatment of patients suffering from OP intoxication The aim of this work is to study the infl uence of genetic variation of PON1 gene on paraoxonase enzyme activity in cases of acute organ phosphorus compounds poisoning.