Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice.

Carmen Maria Claro-Cala,María Dolores Herrera,Rosalía Rodríguez-Rodríguez,Jose Carlos Quintela,Marta Pérez-Montero,María Alvarez De Sotomayor,Javier Miñano

doi:10.3390/nu12020323

Carmen Maria Claro-Cala, María Dolores Herrera + Show 5 more

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https://doi.org/10.3390/nu12020323

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Abstract

Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study investigates for the first time the dietary intervention with a pomace olive oil with high concentrations of the triterpenic acids (POCTA), oleanolic and maslinic acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to a POCTA-diet for 10 weeks, show a substantial reduction of body weight, insulin resistance, adipose tissue inflammation, and particularly, improvement of vascular function despite high caloric intake. This study reveals the potential of a functional food based on pomace olive oil and its triterpenic fraction against obesity progression. Our data also contribute to understanding the health-promoting effects attributable to the Mediterranean diet.

Highlights

Obesity and its metabolic and cardiovascular complications represent a serious threat to the health population of almost every country in the world [1]
The administration of the diet supplemented in POCTA during 10 weeks significantly attenuated body weight gain, reaching an average final body weight of 34.35 ± 1.47 g (n = 7), in contrast to the substantial increase in final body weight observed in obese mice that remained in high-fat diet (HFD) feeding (49.64 ± 2.18 g, n = 6) (Figure 1A,B)
The comes from a pomace olive oil with high of of theatriterpenic acidsstrategy (POCTA), oleanolic and present investigation demonstrates theconcentrations beneficial effect dietary-based in which high fat maslinic acid, in obesityand vascular-associated complications

Summary

Introduction

Obesity and its metabolic and cardiovascular complications represent a serious threat to the health population of almost every country in the world [1]. Given the limited success of pharmacological interventions to effectively fight against obesity, dietary-based strategies have shown promising effects as part of the treatment of obesity and cardiovascular complications in pre-clinical and clinical studies [5,6,7,8]. In this sense, the Mediterranean diet as part of a lifestyle is considered as one of the best models of healthy eating. Within the Mediterranean diet, olive oil is a key component, which is partly responsible for the health-promoting effects of this diet, since it provides an excellent lipid matrix

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