Abstract
Polyvinylpyrrolidone (PVP), a macromolecule surfactant, was used to modify the carbon paste electrode (CPE). The electrochemical behavior of acyclovir was studied, and a sensitive oxidation peak at 1.03V was observed in pH5 acetate buffer. Compared with the unmodified CPE, the resulting PVP-modified CPE greatly increased the oxidation signal of acyclovir, exhibiting strong surface enhancement effect. The oxidation mechanism of acyclovir was discussed. It was found that the oxidation of acyclovir involved two electrons and two protons. The influences of pH value, amount of PVP, accumulation potential and time were examined on the oxidation signal of acyclovir. As a result, a novel electrochemical method was developed for the detection of acyclovir. The linear range was from 1×10−8 to 7.5×10−7M, and the detection limit was 2.5×10−9M. The proposed method was demonstrated using acyclovir injection and tablets, and the accuracy was tested using high performance liquid chromatography.
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