Year-end Sale % OFF 
Abstract
Periocular povidone-iodine (PI) and polyvinyl alcohol-iodine (PAI) have had a major role in the prevention of endophthalmitis. The purpose of this study was to investigate the corneal epithelial toxicity of PAI in a rabbit eye model using corneal resistance (CR) measurement, which is a good indicator of cell barrier function. Rabbit eyes were administered PAI solution at 4-, 6-, 8-, or 16-fold dilution with physiological saline solution (saline) or saline alone (control), to the conjunctival sac with/without wash-out with saline. Corneal epithelial injury assessed by fluorescein staining and the CR ratio was measured at 10 minutes (min) to 96 hours (h) after the initial administration. Histological observation was performed in the eyes following the PAI or control administrations. At 120 min after administration of PAI solution, the CR ratio was decreased and superficial punctate keratopathy (SPK) was significantly increased in each of the PAI-administered groups compared to the control. Recovery of CR and SPK after administration of 6- or 8-fold dilution of PAI was significantly delayed in eyes that were not subsequently washed with saline compared with eyes that were. Pre- or post-instillation of 2% rebamipide ophthalmic suspension significantly reduced PAI induced-SPK and -decrease of CR ratio. The CR method was able to accurately and quantitatively evaluate fine corneal epithelial injury. It is suggested that eyes should be washed with saline solution after administration of PAI solution or the instillation of rebamipide to prevent or reduce corneal epithelial injury.
Highlights
Endophthalmitis is a rare but potentially devastating complication of cataract surgery
Corneal epithelial damage after polyvinyl alcohol-iodine (PAI) treatment was detected by FL and graded by observation with a cobalt blue filter under a slit-lamp microscope (Fig 1)
We reported first time that PAI induces corneal epithelial injury in an in vivo rabbit eye model
Summary
Endophthalmitis is a rare but potentially devastating complication of cataract surgery. Rates of endophthalmitis after cataract surgery have ranged from 0.03% to 0.70% [1,2,3]. There is great variability in endophthalmitis prophylaxis practice patterns worldwide. Periocular povidone-iodine (PI) was once universally adopted and considered to be the standard of eye care in most practices. PI is most widely used as a preventive agent largely because of its strong bactericidal effects on many strains of bacteria, including drug-resistant bacteria, viruses, and other pathogens [4].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
