Abstract

An efficient synthesis of poly-valent difluorinated zanamivir modified polymer as strong inhibitor of influenza virus was reported. Specifically, the mono difluorinated zanamivir with an azide linker was attached on alkynlated [poly (methyl vinyl ether-alt-maleic anhydride)] via “Click Chemistry” to afford polyvalent glycopolymer. The neuraminidase inhibition assay against H7N9 virus like particle showed an enhanced anti-influenza virus activity with IC50 value at least 1000 fold better than that of the difluorinated zanamivir monomer.

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