Polyurethane-Grafted Chitosan as New Biomaterials for Controlled Drug Delivery

Abstract

The present investigation focuses on the grafting of chitosan (CHT) with diisocyanate terminated polyurethane. Solid state 13C NMR spectroscopy confirms the grafting reaction and the degree of substitution (DS) was calculated from the deconvoluted area of the corresponding NMR peak. Solubility studies, swelling behavior and contact angle measurements support the hydrophobic chemical modification on CHT molecules and higher DS leads to the cross-linking of CHT molecules having polyurethane bridges resulting insolubility and regulated swelling in the graft copolymer. Molecular relaxations phenomena due to the constraint associated with the grafting have been revealed using spin–lattice relaxation tine (T1) and shifting of peak position in tan δ curve toward lower temperature in dynamic mechanical measurement at constant frequency indicating flexible nature of graft copolymers as compared to pure CHT. The sustained drug delivery has been achieved using graft copolymers vis-a-vis pure CHT following the Fickia...