Abstract
The current study was proposed in order to obtain, to characterize by usually physico-chemical methods and to assess in vitro, the potential cytotoxic effect of polyurethane microstructures loaded with epigallocatechin gallate (PU_MS) on human pharyngeal carcinoma cells (Detroit 562) and squamous cell carcinoma (SCC-4). The results showed that polyurethane microstructures obtained are stable and have dimensions that make them biocompatible with the biological environment. The cytotoxicity of test samples is dependent on concentration and 72 hours after stimulation at the highest concentration tested the viability of tumor cells was below 50%, the decrease being much more pronounced in the case of squamous cell carcinoma. The novel nanostructures loaded with epigallocatechin gallate induced an augmented cytotoxic effect, suggesting that this drug carriers are suitable to enhance the antitumor effect of epigallocatechin gallate.
Highlights
IntroductionDespite all the efforts made, the affected population is increasing and the survival rate in the case of patients varies greatly depending on the type of cancer, stage, age, country, etc
The discovery of active molecules against cancer has grown in the last decade
The aim of the current study was to obtain polyurethane structures loaded with epigallocatechin gallate and to realize a preliminary evaluation of the compounds obtained on pharyngeal carcinoma cells and squamous cell carcinoma
Summary
Despite all the efforts made, the affected population is increasing and the survival rate in the case of patients varies greatly depending on the type of cancer, stage, age, country, etc. The survival rate in developed countries is significantly higher compared to poorly developed or developing countries. Compounds from natural sources are an alternative used effectively in the study of anticancer drugs. The most relevant examples of anticancer drugs obtained from natural sources are given by Paclitaxel, vincristine and doxorubicin [1,2,3]. Despite the efforts, obtaining medicines from natural sources is not an easy one and depends on a series of factors such as: correct selection of isolation and separation methods, the influence of yield, evaluation method, legislation in force, etc
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