Abstract
The purpose of this study was to evaluate the process of bone repair in surgical defects created in parietal bone of rabbits by the guided bone regeneration technique, using polyurethane (PUr) and PTFE barriers. The surface characteristics of the barriers in scanning electronic microscopic were also evaluated. In this research, 24 adult rabbits were used, 12 were in control group (C) and 12 were in experimental groups (right parietal – PUr group and left parietal – PTFE group). In the C group, the defect was filled only by blood clot. In the experimental groups, the PUr and PTFE barriers were positioned on the floor and on the surface of each bone defect. After 15, 30, 60 and 90 days, 3 animals in the C and 3 in the experimental groups were sacrificed and the defect bones were submitted to microscopic analysis. The results of the study showed no significant differences in the experimental groups, demonstrating quantitative and qualitative superiority bone fill and faster bone regeneration when compared to the C group. The physical barriers presented homogenous surface and no porosity. The PUr was biocompatible, osteoconductive and was not absorbed during the process of bone repair.
Highlights
The treatment of the defects in the maxillary bone is a complex process influenced by age, bone structure, blood supply, defect morphology and adjacent soft tissue
15 days The bone defect of the C group showed bone defect filled by osteogenic connective tissue and for immature bone trabeculae
Hemorrhage interstitial areas and infiltrated of mononucleares inflammatory cells were present in the experimental groups (Figure 2)
Summary
The treatment of the defects in the maxillary bone is a complex process influenced by age, bone structure, blood supply, defect morphology and adjacent soft tissue. The PTFE barrier has been successfully used in experimental and clinical studies, once for not presenting porosity it hinders the bacterial colonization, allowing its exhibition to the oral cavity, besides the fact of presenting biocompatibility, low cost and easy manipulation[15,16,17]. A natural polyurethane (PUr) resin obtained by polymerization of the polyester polyol, derived from Ricinus communis, a tropical castor bean, has been developed for bone repair[4,12]. PUr barrier was developed to be applied in GBR and this polymeric had their properties described as being biocompatible, osteoconductor, antimicrobial, absorbable and having osseointegrate properties[2,3,5,6,13]. In the barrier form few works were accomplished[1,17]
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