Abstract
Introduction Westernisation of diet is suspected to contribute to a rising incidence of inflammatory bowel diseases across the globe, while specific macronutrients that would trigger gut inflammation remain largely elusive. We recently demonstrated that Crohn’s disease (CD) patients exhibit impaired activity of the antioxidative enzyme glutathione peroxidase 4 (GPX4) specifically in intestinal epithelial cells. Mice lacking one allele of Gpx4 in the intestinal epithelium develop a Crohn’s-like enteritis after dietary challenge with a Western diet enriched with polyunsaturated fatty acids (PUFA). Here, we illustrate how PUFAs evoke gut inflammation in the context of impaired epithelial GPX4 activity.
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