Polyunsaturated fatty acids in a Western diet trigger TLR2-dependent Crohn’s-like enteritis in mice

M Philipp,M Effenberger,G Oberhuber,NC Kaneider,L Mayr,K Aden,TE Adolph,B Enrich,L Niederreiter,Q Ran,S Sprung,V Wieser,F Grabherr,A Kaser,RS Blumberg,J Schwärzler,H Tilg,R Koch,P Rosenstiel

doi:10.1055/s-0041-1734232

Polyunsaturated fatty acids in a Western diet trigger TLR2-dependent Crohn’s-like enteritis in mice

M Philipp, M Effenberger + Show 17 more

https://doi.org/10.1055/s-0041-1734232

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Publication Date: Aug 1, 2021

Affiliation: Universität Innsbruck, Innsbruck Medical University, Addenbrooke's Hospital, University of Cambridge, Kiel University, The University of Texas Health Science Center at San Antonio, The University of Texas Health Science Center, Brigham and Women's Hospital

#Polyunsaturated Fatty Acids #Incidence Of Inflammatory Bowel Diseases + Show 8 more

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Abstract

Introduction Westernisation of diet is suspected to contribute to a rising incidence of inflammatory bowel diseases across the globe, while specific macronutrients that would trigger gut inflammation remain largely elusive. We recently demonstrated that Crohn’s disease (CD) patients exhibit impaired activity of the antioxidative enzyme glutathione peroxidase 4 (GPX4) specifically in intestinal epithelial cells. Mice lacking one allele of Gpx4 in the intestinal epithelium develop a Crohn’s-like enteritis after dietary challenge with a Western diet enriched with polyunsaturated fatty acids (PUFA). Here, we illustrate how PUFAs evoke gut inflammation in the context of impaired epithelial GPX4 activity.

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