Polyunsaturated Fatty Acids Decrease Induced Pathological Disturbances in Rat Pups

Abstract

Early recognition of pathological processes in CNS by the biotesting method allows correcting these processes since the prenatal period. A natural product, epaden, produced from fat of marine hydrobionts ( ω-3-polyunsaturated fatty acids) has an antiaggregation and antioxidant activity, as well as a pronounced adaptogenic, protective, and reducing action. Addition of epaden to diet of pregnant rats decreases twofold fetal lethality under effect of peptide factors causing disturbances of motor activity in newborns, increases viability index, leads to normalization of simple motor acts, and prevents from development of severe motor disorders in rat pups. A preliminary administration of epaden and its simultaneous administration with pathogenic factors produce a more pronounced positive effect than the subsequent treatment of induced embryological and motor disturbances.