Abstract

We compared the polyunsaturated fatty acid (PUFA) status of Dutch vegans and omnivores to investigate whether disparities can be explained by different diets and long chain PUFA (LCP) synthesis rates. Dietary intakes and fatty acid compositions of erythrocytes (RBC), platelets (PLT), plasma cholesterol esters (CE) and plasma triglycerides (TG) of 12 strict vegans and 15 age- and sex-matched omnivores were determined. Vegans had higher ω6 (CE, TG), 18:2ω6 (RBC, CE, TG), 18:3ω6 (TG), 20:3ω6 (TG), 22:4ω6 (TG), 22:5ω3 (RBC, PLT), 22:5ω3/22:6ω3 (RBC, PLT) and 22:5ω6/22:6ω3 (RBC, PLT), and lower 22:4ω6 (RBC, PLT), 22:4ω6/22:5ω6 (RBC, PLT), ω3 (CE), LCPω3 (CE, TG), 20:5ω3 (RBC, PLT, CE), 22:5ω3 (TG) and 22:6ω3 (all compartments). Vegans had lower 20:4ω6 (TG) after normalization of PUFA to 100%, and normalization of eicosanoid precursors to 100% revealed similar 20:4ω6 (all), higher 20:3ω6 (TG) and lower 20:5ω3 (all). High ω6 (notably 18:2ω6) and low ω3 (notably 20:5ω3, 22:6ω3) status in Dutch vegans derives from low dietary LCPω3 and 18:3ω3/18:2ω6 ratio. Higher 18:3ω6 and 20:3ω6 in their TG may reflect higher hepatic 20:4ω6 production rate, whereas higher 20:4ω6 and 22:4ω6 in omnivores indicates 20:4ω6 intake from meat.

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