Polythiophene silver bromide nanostructure as ultra-sensitive non-enzymatic electrochemical glucose biosensor

Abstract

In current study, we developed a highly stable electrocatalyst via integration of AgBr particles into the polymeric structure of polythiophene through the doping process that formed a highly active catalysis for rapid/repeatable oxidation of glucose via electrochemical approaches for real time detection of blood sugar. The developed platform consisted of highly crystalline polythiophene-AgBr (PT-AgBr) that exhibited a well-ordered hybrid cubic/nanorode morphology with positive zeta potential value and electrophoretic mobility of 16.7 mV/0.000129 cm2/Vs, respectively. Moreover, examination of the developed platform via CV and amperometric techniques revealed the superior performance/accuracy of the fabricated biosensor and showed limit of detection (LOD) / sensitivity of 370 nM/756 µA mM−1 cm−2 and 310 nM/10.4 µA mM−1 cm−2 for CV and amperometric techniques, respectively. More importantly, PT-AgBr can detect the glucose through a real-time approach with accuracy more than 99% at day 1 and more than 90% till day 14, while presence of interfering compounds within the biological/non-biological samples has negligible effect on the sensing performance of developed biosensor. Evaluation of real samples furtherly confirmed the superior role of the PT-AgBr that recovered about 97.1% of the glucose within the human blood plasma containing plenty of annoying species.