Polytheonamides, unprecedented highly cytotoxic polypeptides, from the marine sponge theonella swinhoei: 1. Isolation and component amino acids

Abstract

Highly cytotoxic polypeptides, polytheonamides A-C, have been isolated from the marine sponge Theonella swinhoei. Interpretation of the 2D NMR data of the acid hydrolyzate of polytheonamide B as well as amino acid analysis led to identification of Ala, Asp, Thr, aThr, Ser, Glu, Val, Gly, Ile, t-Leu, β-methylGlu, β-methylIle, β-hydroxyVal, and β-hydroxyAsp. 2D NMR data of polytheonamide B suggested the presence of γ-hydroxy- t-Leu, which was a new amino acid.