Polyspecific IgG against mumps, rubella and measles in paediatric population with neuroinflammation process in vaccine failure conditions

Abstract

Event Abstract Back to Event Polyspecific IgG against mumps, rubella and measles in paediatric population with neuroinflammation process in vaccine failure conditions Ivonne M. Iglesias Gonzalez1*, Barbara Padilla Docal1, Alberto J. Dorta Contreras1 and Ricardo Junco Calzadilla1 1 Laboratorio Central de Liquido Cefalorraquideo (LABCEL) Facultad Miguel Enriquez Univesidad de Ciencias Medicas de la Habana, Cuba Introduction: The vaccines combined trivalent against mumps, rubella and measles have been used during years in United States and in the greater part of the European countries. Also several Latin American countries have included this vaccine in their national vaccination program. Objective: Determine according to the polyspecific answer anti IgG mumps, rubella and measles in a children population with neuroinfammation process if a vaccine failure was produced. Material and methods: Pediatric patients suffering from viral meningoencephalitis during 2009-12. Previously, the patients were immunized with against with a trivalent vaccine againt mumps, rubella and measles. Serum and cerebrospinal fluid (CSF) IgG and albumin were quantified by immunodiffusion to determine intrathecal IgG synthesis and virus specific IgG antibody index by ELISA technique. Results: IgG intrathecal synthesis were presented without blood-CSF dysfunction. CSF and serum anti-mumps IgG were significant positive correlationate and between measles antibody index with age of the patients and answer time but not in anti rubella and anti measles antibody index with age and answer time and vaccination year. Conclusions: A vaccination failure was produced in this children population according to their polyspecific IgG antibodies against measles, rubella and mumps and correlated with epidemiology findings. Keywords: Vaccine failure, neuroimmunology response, Measles, Mumps Vaccine, Rubella Vaccine Conference: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015. Presentation Type: Poster Presentation Topic: Immunotherapy Citation: Iglesias Gonzalez IM, Padilla Docal B, Dorta Contreras AJ and Junco Calzadilla R (2015). Polyspecific IgG against mumps, rubella and measles in paediatric population with neuroinflammation process in vaccine failure conditions. Front. Immunol. Conference Abstract: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología. doi: 10.3389/conf.fimmu.2015.05.00077 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 06 Mar 2015; Published Online: 14 Sep 2015. * Correspondence: Dr. Ivonne M Iglesias Gonzalez, Laboratorio Central de Liquido Cefalorraquideo (LABCEL) Facultad Miguel Enriquez Univesidad de Ciencias Medicas de la Habana, Havana, Havana, 10700, Cuba, iigonzalez@infomed.sld.cu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ivonne M Iglesias Gonzalez Barbara Padilla Docal Alberto J Dorta Contreras Ricardo Junco Calzadilla Google Ivonne M Iglesias Gonzalez Barbara Padilla Docal Alberto J Dorta Contreras Ricardo Junco Calzadilla Google Scholar Ivonne M Iglesias Gonzalez Barbara Padilla Docal Alberto J Dorta Contreras Ricardo Junco Calzadilla PubMed Ivonne M Iglesias Gonzalez Barbara Padilla Docal Alberto J Dorta Contreras Ricardo Junco Calzadilla Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.