Abstract
The study included 43 patients in UWS /VS and MCS (impaired consciousness 15 ± 4 months). All patients were assessed by CRS-R, PSG ( for each patient was 12–20 h), levels of melatonin, cortisol, prolactin, ACTH and GH were studied (at 8.00, 15.00, 21.00, 00.00, 3.00). Daily melatonin level in urine. Patients were divided in 2 groups : group 1 TBI (n = 35); group 2 - Hypoxia (n = 8). Results of PSG and hormone levels were compared with the etiology of brain damage and further recovery of consciousness. In 35 patients, clear sleep staging was observed, patients without staging (8) were in the VS/UWS. Maximum levels of melatonin at 3.00 and a minimum - at 15.00 was observed in patients after TBI. In the group of hypoxia, more physiological levels were registered in MCS patients. Analysis of melatonin level in urine revealed the prevalence of night increase in the UWS group compared with MCS. Study of ACTH, cortisol, revealed inversion of cortisol and ACTH secretion rhythm, with increase at 21 and 24 pm, that could be a sign of allostasis.GH and prolactin secretion rhythms showed a similar nature of their secretion rhythms for patients in the UWS and MCS in the TBI group; in the group of non-traumatic genesis, most physiological values were shown for patients in MSC. The study was funded by the Russian Foundation For Basic Research (RFBR) project number 19-29-01066/2019
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
