Abstract
BackgroundSleep disturbances are common non-motor symptoms of Parkinson’s Disease (PD).MethodsThe aim of this study was to investigate the polysomnographic correlates of sleep changes, as investigated by the Parkinson’s Disease Sleep Scale-2 (PDSS-2), in a cohort of sixty-two consecutive de novo, drug naïve PD patients (71.40 ± 7.84 y/o).ResultsPDSS-2 total score showed a direct correlation with stage shifts (p = 0.008). Fragmented sleep showed an inverse correlation with sleep efficiency (p = 0.012). Insomnia symptoms showed an inverse correlation with wake after sleep onset (p = 0.005) and direct correlation with periodic leg movements (p = 0.006) and stage shift indices (p = 0.003). Motor Symptoms showed a direct correlation with Apnoea-Hypopnoea (AHI; p = 0.02) and awakenings indices (p = 0.003). Dream distressing showed a direct correlation with REM without atonia (RWA, p = 0.042) and an inverse correlation with AHI (p = 0.012). Sleep quality showed an inverse correlation with RWA (p = 0.008).ConclusionPDSS-2 features are significantly correlated with polysomnography objective findings, thus further supporting its reliability to investigate sleep disturbances in PD patients.
Highlights
Sleep disturbances are among the most common non-motor symptoms of Parkinson’s Disease (PD) [1]
We investigated the clinical and polysomnographic correlates of sleep disorders in a naturalistic group of consecutive de novo, drug naïve PD patients, providing a reliable characterization of such disturbances
25.8% of our patients presented with sleep disturbances, according to the Parkinson’s Disease Sleep Scale-2 (PDSS-2) total score
Summary
Sleep disturbances are among the most common non-motor symptoms of Parkinson’s Disease (PD) [1] These disturbances mostly include insomnia (i.e., difficulties in both falling and staying asleep), fragmentation of sleep, excessive daytime sleepiness and abnormal movements and behaviours, such as periodic limb movements (PLMs) and rapid eye movement sleep behaviour disorder (RBD) [2,3,4]. Besides sleep fragmentation and RBD, several other sleep disturbances are often present in PD patients, at any stage of the disease, affecting patients’ quality of life. Sleep disturbances are common non-motor symptoms of Parkinson’s Disease (PD). Insomnia symptoms showed an inverse correlation with wake after sleep onset (p = 0.005) and direct correlation with periodic leg movements (p = 0.006) and stage shift indices (p = 0.003). Conclusion PDSS-2 features are significantly correlated with polysomnography objective findings, further supporting its reliability to investigate sleep disturbances in PD patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
