Abstract
Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy. Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells. PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells. These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.
Highlights
Combined immunotherapy and chemotherapy is one of the most efficient strategies for treating cancer
Effect of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) on cell viability of THP-1 monocytes The data showed that biomass of mycelium from C. militaris was significantly increased in porcine liver extracts medium when compared with the basal medium or the de-fat soybean extracts medium by surface liquid cultivation (Supplemental Figure 1A)
We evaluated polysaccharides production of surface liquid-cultured C. militaris by different substrates, including polysaccharides obtained from mycelia of C. militaris grown in basal medium, polysaccharides obtained from mycelia of C. militaris grown in porcine liver extracts medium, and polysaccharides obtained from mycelia of C. militaris grown in defat soybean medium
Summary
Combined immunotherapy and chemotherapy is one of the most efficient strategies for treating cancer. It is important to design an effective treatment program which can optimize immunotherapy and chemotherapy to diminish side effects.[1] Clinical evidence shows that eliminating cancer via the immune system is promising and will propel more research in immunotherapy. Many studies have been done to use the most appropriate. The use of complementary and alternative medicine has become a popular option to support the conventional therapy in many areas.[2,3,4] For example, many herbal formulas and remedies based on the traditional Chinese medicine are well accepted among cancer patients with Chinese background.[5,6,7]
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