Abstract
Dry tuberous roots of ophiopogon japonicus are famous Chinese herbal medicines. Several studies have been shown that polysaccharide is one of the main active ingredients of ophiopogon japonicus and plays an important role in pharmacological action. In the study, the effects of polysaccharides from ophiopogon japonicus (POJ) on the oxidative damage induced by strenuous exercise were investigated. Male mice were randomly divided into four groups and designated as high-dose POJ-treated, medium-dose POJ-treated, low-dose POJ-treated and control groups, which received 80, 40, and 20 mg/kg POJ and physiological saline, respectively, by gavage once a day for 28 days. This was followed by an exhaustive running exercise and measurements of various biochemical parameters from blood and muscles tissue. The results showed that POJ could significantly prolong the exhaustive running time of mice, decrease the levels of lactate dehydrogenase (LDH), creatine kinase (CK) and 8-Hydroxy-2′-deoxyguanosine (8-OHdG) in blood, and malondialdehyde (MDA) levels in muscle, which were accompanied by corresponding increased levels of superoxide disproportionation enzyme (SOD), glutathione peroxidase (GPx), and catalase (CAT) in muscle. The data suggest that POJ have protective effects on strenuous exercise-induced oxidative damage.
Highlights
There are few studies on the effects of polysaccharides from ophiopogon japonicus (POJ) on oxidative damage caused by strenuous physical exercise
This study used exhaustive exercised-mouse model to study the protective effects of POJ on strenuous exercise-induced oxidative damage by measuring the changes of various biochemical parameters, which would provide a theoretical basis for the development of POJ as a related exercise supplement to improve the body's oxidative stress
Compared with the C group, the exhaustive running times of high-dose POJ-treated (HPOJ), medium-dose POJ-treated (MPOJ), and low-dose POJ-treated (LPOJ) groups were significantly prolonged (p
Summary
Dry tuberous roots of ophiopogon japonicus (known as MaiDong) are famous Chinese herbal medicines, which have the effect of quenching thirst, moistening lungs and relieving cough. Recent literature has reported that ophiopogon japonicus extracts have anti-oxidation, anti-fatigue, anti-arrhythmia, hypoglycemic, cellular immune function and recovery of islet cell function [2,3,4]. The main chemical components of Ophiopogon japonicus are polysaccharides, steroidal saponins, amino acids, etc. Polysaccharide is one of the main active ingredients of ophiopogon japonicus and plays an important role in pharmacological action [5]. There are few studies on the effects of polysaccharides from ophiopogon japonicus (POJ) on oxidative damage caused by strenuous physical exercise. This study used exhaustive exercised-mouse model to study the protective effects of POJ on strenuous exercise-induced oxidative damage by measuring the changes of various biochemical parameters, which would provide a theoretical basis for the development of POJ as a related exercise supplement to improve the body's oxidative stress
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