Abstract
Smart magnetic nanosystems have attracted particular attention among the various anti-cancer drug delivery systems. Such nanocarriers provide easy control of the location of drugs in the patient's body. On the other hand, minimizing the toxicity of magnetic nanoparticles is an important issue during the fabrication of magnetic-based smart carriers. Polysaccharides, such as starch, chitosan, hyaluronic acid, dextran, cellulose, alginate, etc., are known as natural polymers and have been shown to improve significantly the biocompatibility and biodegradability of magnetic nanocarriers. This review summarizes recent research on polysaccharide-modified magnetic nanocarriers, highlighting their fabrication and application in cancer chemotherapy. First, the role of magnetic nanoparticles in cancer therapy and drug release mechanisms from such nanocarriers have been introduced. Then, magnetic nanocarriers have been classified according to their structure. Loading and release mechanisms and target cancer cells have also been investigated in each case. Most anticancer drugs (such as doxorubicin, paclitaxel, 5-fluorouracil, etc.) frequently used in the polysaccharide-modified magnetic drug nanocarriers are covered by this review; some other unfamiliar ones are also mentioned.
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