Abstract
AbstractIndomethacin was encapsulated in oil‐core capsules stabilized by carrageenan/chitosan film formed through subsequent electrostatic adsorption of oppositely charged polysaccharides on lecithin‐stabilized oil‐in‐water emulsion droplets. In order to investigate the influence of the physicochemical properties of polysaccharides on drug encapsulation, chitosan samples with different degrees of acetylation (DA) and molecular weight (Mw) were chosen in this study. The variation of the electrokinetic charge and hydrodynamic diameter of the droplets were measured after each adsorption step by Dynamic light scattering. The experimental results indicated that the diameter of the loaded capsules and encapsulation efficiency of the drug (in the range of 70 %–94 %) depend on the Mw of the chitosan. The electrokinetic measurements indicated the achievement of overcompensation of the surface charge and re‐stabilization of the dispersion after each deposition step.
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