Abstract
Background : Heart disease is the leading cause of death for both men and women, but heart disease is preventable and controllable. Ganoderma lucidum is widely used as traditional medicine for centuries particularly in China, Japan, and Korea. Previous study showed antioxidative activity of polysaccharide peptide (PsP) from Genoderma lucidum.Objective : This study was aimed to evaluate anti-inflammatory and antioxidant effect of polysaccharide peptide (PsP) from Ganoderma lucidum in atherosclerotic rats.Methods : The atherosclerotic rats were randomly divided into four groups (5 rats each group) : atherosclerotic model with high-fat diet, low dose PsP treated group (50 mg/kgBW), medium dose PsP treated group (150 mg/kgBW), high dose PsP treated group (300 mg/kgBW), with normal mice used as a control group. Parameters measured were the level of MDA, SOD, IL - 6 , IL - 10, hsCRP, TNF - ?, lipid profile and foam cell.Results : After PsP therapy for 5 weeks, the levels of MDA (p=0.01), hsCRP (p=0.018) in rats model of atherosclerosis decrease significantly. PsSP can reduce levels of IL - 6 (p=0.933) and increase levels of SOD (p=0.28) descriptively at PsP doses 150 mg/kgBW. While the levels of TNF-? (p=0.894) and IL-10 (p=0.98) was not affected by administration of PsP. PsP improve the lipid profile by increasing HDL (p=0.002) and lowering total cholesterol (p=0.04). The formation of foam cells (p=0.024) as a marker of atherogenesis significantly decreased by administration of PsP .Conclusion : PSP can be useful to reduce inflammatory processes and oxidative stress to prevent the process of atherogenesis.
Highlights
Heart disease is one of the leading causes of mortality in the world
Atherosclerosis is caused by inflammation or chronic inflammation produced by macrophages, polymorfonuclear cells, and his cytokines.[2]
This study was conducted to determine the effect of poly- saccharides Peptide (PsP) in inhibiting the formation of atherosclerosis in atherosclerosis rats induced by High Fat Diet (HFD)
Summary
Heart disease is one of the leading causes of mortality in the world. It is shown that 48 % of deaths in the worldJurnal Kardiologi Indonesia related with non-infectious diseases, is cardiovascular disease. Atherosclerosis is caused by inflammation or chronic inflammation produced by macrophages, polymorfonuclear cells, and his cytokines.[2]. It has recently been developed herbal medicine as complementary therapy on CHD patients including Ganoderma lucidum. Several studies have shown Ganoderma Lucidum extract useful on CHD, clinically improving clinical complaints, lowering total serum cholesterol, improves ECG and blood pressure.v In addition the study showed benefits in Scandinavia, extracts of the fungus Saccharomyces cerevisiae wall containing β-glucan given to patients undergoing CABG, which decreases the inflammatory response and protect the heart from reperfusion injury.[4] But only limited study focus in effect of Ganoderma lucidum in chronic inflammation and oxidative stress in atherogenesis. Conclusion : PSP can be useful to reduce inflammatory processes and oxidative stress to prevent the process of atherogenesis
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