Abstract
Drug-induced kidney injury (DIKI) refers to kidney damage caused by nephrotoxic drugs. Unfortunately, there are no effective prevention measures. Here, the protective effect of polysaccharide from Cordyceps cicadae (CCPa) on DIKI was evaluated. The results of in vivo experiment showed that the kidney injury induced by gentamicin (GM) was significantly improved after CCPa intervention. For instance, CCPa could ameliorate renal function (the levels of SCr and BUN) and renal pathological damage, inhibit the inflammatory factors (IL-6 and TNF-α) and reduce the amount of apoptotic cells in the kidney. Furthermore, both in vivo and in vitro experiments showed that CCPa dose-dependently inhibited mitochondrial apoptosis and regulated the expression of Bax/Bcl-2/caspase-3 pathway-related proteins, thus playing a protective role in kidney. The results provided a basis for the prevention of CCPa on DIKI and CCPa could be developed as a healthy food or drug for kidney protection.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
