Abstract
Polymeric membranes are a viable and sustainable option for the biotechnology industry from an economic and environmental point of view. In this study, we evaluated tissue response and tolerance to the implantation of a polymeric membrane prepared with cashew gum polysaccharide (CGP) associated with polyvinyl alcohol (PVA). The objective was to characterize the biocompatibility of the CGP/PVA membrane in vivo. Following the evaluation criteria of the ISO 10993-6 standard, we demonstrated that the CGP/PVA membrane showed moderate tissue reaction, with a non-irritating ISO pattern, a thinner fibrous capsule, and a smaller amount of collagen compared to the positive control group. At 30 and 60 days, the membrane presented a similar amount of mast cells to that observed in the negative control group. The data demonstrate that the CGP/PVA membrane presents biocompatibility in accordance with the ISO 10993-6 standard.
Highlights
Polysaccharides have attracted increasing attention as promising materials for the development of biomedical devices due to their easy availability, non-toxicity, biocompatibility, biodegradability, renewability, and modifiable character [1]
Cashew gum (CG) is a polysaccharide obtained from the resin of the trunk and branches of Anacardium occidentale L., popularly known as cashew, and composed mainly of galactose and arabinose [4,5]
Schirato et al [9] suggest that cashew gum polysaccharide (CGP) improves the inflammatory stage of the wound healing process
Summary
Polysaccharides have attracted increasing attention as promising materials for the development of biomedical devices due to their easy availability, non-toxicity, biocompatibility, biodegradability, renewability, and modifiable character [1]. CG is known for its various qualities, such as antimicrobial activity [6,7,8], healing [9], anti-inflammatory [10], immunomodulatory [11], antidiarrheal [12], gastroprotective [13], anti-asthmatic, and anti-diabetic [14], and larvicide-encapsulating agent in the form of nanoparticles [15], and it presents cytotoxicity in tumor lines [16]. Schirato et al [9] suggest that cashew gum polysaccharide (CGP) improves the inflammatory stage of the wound healing process. Despite their biodegradability, the use of natural polymers results in a material with lesser mechanical properties [1,17]. An alternative to solve this problem is the production of a blend, where two or more materials are mixed to form the final product, which may have intermediate properties between the displayed properties of each constituent material
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