Abstract
Smart conductive materials are developed in regenerative medicine to promote a controlled release profile of charged bioactive agents in the vicinity of implants. The incorporation and the active electrochemical release of the charged compounds into the organic conductive coating is achieved due to its intrinsic electrical properties. The anti-inflammatory drug dexamethasone was added during the polymerization, and its subsequent release at therapeutic doses was reached by electrical stimulation. In this work, a Poly (3,4-ethylenedioxythiophene): κ-carrageenan: dexamethasone film was prepared, and κ-carrageenan was incorporated to keep the electrochemical and physical stability of the electroactive matrix. The presence of κ-carrageenan and dexamethasone in the conductive film was confirmed by µ-Raman spectroscopy and their effect in the topographic was studied using profilometry. The dexamethasone release process was evaluated by cyclic voltammetry and High-Resolution mass spectrometry. In conclusion, κ-carrageenan as a doping agent improves the electrical properties of the conductive layer allowing the release of dexamethasone at therapeutic levels by electrochemical stimulation, providing a stable system to be used in organic bioelectronics systems.
Highlights
Conductive polymers are a new generation of smart materials extensively used in organic bioelectronics, mostly in the development of neural implants, biosensors, and active controlled release systems [1,2,3,4]
The chemical composition inside the conductive film was confirmed by 2D Raman and electrochemical signal in the cyclic voltammetry analysis
Concentrations of dexamethasone in the range of 100 to 1000 nM were obtained using a lower amount of dexamethasone in the initial formulation
Summary
Conductive polymers are a new generation of smart materials extensively used in organic bioelectronics, mostly in the development of neural implants, biosensors, and active controlled release systems [1,2,3,4]. PEDOT is reported as a promising material for the immobilization of enzymes and other biologically active molecules [2,7,8]. Molecules 2020, 25, 2139 reported to be dependent on the polymer thickness and charge applied during the electrochemical stimulus [10,11,12,13]. Diverse implants and scaffolds are developed in regenerative medicine to serve as extracellular matrices for cell colonization [14,15,16]. Many of them are loaded with bioactive agents to improve the therapeutic efficacy and safety of the drugs, playing important roles in treatment of several chronic diseases, damaged tissues, and providing a potential stimulation of different types of cells [17,18,19]
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