Abstract
Apost-synthetic integration of polypyrrole ontoNU-1000 MOF (PPy@NU-1000) was done by pyrrole adsorption, followed by oxidative polymerization. The synthesized materials were characterized by XRD, SEM, BET, and FTIR. The ultra-high specific surface areawithhigh-density catalytic sites of NU-1000 (2223m2g-1) was combined with theelectrical conductivityof PPy (2-100Scm-1). PPy@NU-1000 providessuperior electrocatalytic activity and charge transfer properties compared to an individual component. ThePPy@NU-1000-modified GCE was applied to detect thebiomolecule Levodopa (LD). The DPV oxidation peak of LD was strongest at 272 ± 10mV vs.Ag/AgCl reference electrode. Under the optimized experimental condition, the fabricated electrochemical sensor exhibited a wide quantification range of 0.005-70μM with a sub-nanomolar detection limit of 0.0001μM (S/N 3). The described sensor exhibits high sensitivity (2.08μAμM-1cm-2) with reasonable stability, reproducibility, and selectivity for the detection LD in the presence of potentially interfering compounds. Furthermore, human serum analysis showed excellent recovery values within the range 99.3-101.6%. Validation of the method was performed against HPLC.Graphical abstract.
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