Abstract
A rare naturally-occurring polyprenylated isoflavanone, designated ormosinol ( 1), and a new isoflavonoid glycoside, named ormosinoside ( 2), along with 21 known compounds were isolated from the root bark of Ormosia henryi Prain. The structures of compounds 1 and 2 were determined as 5,7,2′,4′-tetrahydroxyl-6,8,5′-tri-(γ,γ-dimethylallyl)isoflavanone and isoprunetin-7- O-β- d-xylopyranosyl-(1 → 6)-β- d-glucopyranoside on the basis of a combination of 1D-, 2D-NMR and mass spectroscopic measurements. Compound 1 showed significant anti-oxidation activity against DPPH radicals (IC 50 28.5 μM) and cancer cell line (A549, LAC, and HepG2) growth inhibitory activity with IC 50 ranging from 4.25 to 7.09 μM, while compound 2 found to be inactive to both testing systems.
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