Abstract
Three new polyprenylated acylphloroglucinol meroterpenoids, hyperiforins A–C (1–3), were isolated from Hypericum forrestii (Chittenden) N. Robson, together with twelve known analogues (4–15). Their structures were established by extensive physical and spectroscopic data analysis. Compounds 1, 2, 5, 7, and 13–15 showed potent inhibitory effects on protein tyrosine phosphatase 1B with IC50 values from 6.63 ± 2.40 to 14.21 ± 3.51 μM.
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