Abstract
Hepatic cell suspensions were used for volume measurements of nucleoli. Nucleolar volumes, within the hepatic cell population, show a characteristic frequency distribution with increasing ploïdy. Hypophysectomy reduces nucleolar volume and the frequency of large nucleoli is significantly reduced in favor of small nucleoli without change in total number of nucleoli per cell. Protein deficiency, known to increase nucleolar volume in intact animals, does not reverse this situation. However cell proliferation induced by hepatectomy is accompanied by an increase in nucleolar volumes despite hypophysectomy. It is concluded that nucleolar function, reflected in the frequency distribution of nucleolar volumes, in hepatic cells is subject to at least two different controls, one of which operates during cell proliferation with priority over the second governed directly or indirectly by the hypophysis.
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