Abstract
Polyploidy occurs through a series of cellular divisions of particular types, the first of which is the formation of binuclear cells. Therefore the liver of an animal must be in a state of growth for polyploid cells to be formed. It is possible to prevent polyploid hepatocytes from appearing by bringing about in young animals either a hypophysis insufficiency or a protein deficiency large enough to stop the development of the animal. The lack of growth inhibits the formation of polyploid cells even if the growth hormone is given by injection. The factors inducing the formation of polyploid cells should therefore be tested by their action on hepatic cell multiplication in baby rats (three weeks old or less) which normally show very few binuclear or polyploid cells.
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