Abstract
Xanthoceras sorbifolia Bunge. is used in traditional medicine in North China. To evaluate the anti-tumor and radical-scavenging activities of X. sorbifolia husks polyphenols and determine their structure-activity relationships, 37 polyphenols 1–37 were obtained by bioassay-guided fractionation. Two new compounds 1–2, and compounds 5, 6, 8, 9, 11, 14–17, 21–25, 27–29, 31, 33, 34, 36, and 37 were isolated from the genus Xanthoceras for the first time. Compounds 1–37 did not show strong cytotoxicity against the four tested tumor cell lines (A549, HepG2, MGC-803, and MFC) compared to paclitaxel and under the conditions tested in the anti-tumor assay, but compounds 3, 4, 7, 8, 10, 18–20, 25, 26, 29, 30, 32, and 35 exhibited stronger radical-scavenging activity than ascorbic acid in a 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt assay. This was the first report on the anti-tumor and radical-scavenging activities of the polyphenols isolated from X. sorbifolia husks. Overall, the present study contributed valuable information concerning X. sorbifolia husks use in medicine and pharmacology.
Highlights
IntroductionXanthoceras sorbifolia Bunge. is the only species in the genus Xanthoceras (family Sapindaceae) and is distributed in North China [1]
Xanthoceras sorbifolia Bunge. is the only species in the genus Xanthoceras and is distributed in North China [1]
The molecular formula was determined as C14 H20 O9 by high resolution electrospray ionization mass spectrometry (HR-ESI-MS) at m/z 355.1003 [M + Na]+
Summary
Xanthoceras sorbifolia Bunge. is the only species in the genus Xanthoceras (family Sapindaceae) and is distributed in North China [1]. Is the only species in the genus Xanthoceras (family Sapindaceae) and is distributed in North China [1]. This species is a kind of woody oil-bearing crop, traditionally used in herbal medicine for curing atherosclerosis, rheumatism, hyperpiesia, chronic hepatitis, and child enuresis [2], and it has been included in the 1977 edition of the China Pharmacopoeia [3]. Medical research showed that X. sorbifolia husk components improved learning ability and memory [7], had anti-cancer effects [8], inhibited tyrosinase [9], cured cardiovascular diseases [10], had anti-oxidant properties [11], and inhibited pancreatic lipase activity [12]. Anti-tumor and radical-scavenging activities have not yet been reported for the polyphenols isolated from X. sorbifolia husks.
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