Abstract
Effects of long-term application of novel polyphenolic composition BP-C3, containing polyphenolic benzenepolycarboxylic acids, vitamins and minerals on some biomarkers of aging, life span and spontaneous tumorigenesis has been studied in female SHR mice. Administration of BP-C3 with drinking water (0.005%) did not exert any toxic effect (did not have effect on general condition of animals, weight dynamics and consumption of food), postponed age-related switch-off of estrous function, caused slight reduction of body temperature. An increased survival was observed in mice treated with BP-C3 (p=0.00164, log rank test). BP-C3 increased mean lifespan – by 8.4%, lifespan of the last 10% of animals – by 12.4%, and life span of tumor-free mice – by 11.6%. A tendency in ability of BP-C3 to inhibit development of spontaneous tumors in mice was detected, though it did not reach the level of statistical significance (p=0.166, log rank test). The number of malignant mammary tumors was 1.5 times less and total number of tumors of various localizations was 1.6 times less in BP-C3 treated animals. Multiple tumors were registered in 8% of mice in the control group and no cases – in BP-C3 treated group. Thus, BP-C3 demonstrated some anti-carcinogenic and a pronounced geroprotective activity.
Highlights
BP-C3 is a composition jointly developed by N.N
Effects of long‐term application of novel polyphenolic composition BP‐C3, containing polyphenolic benzenepolycarboxylic acids, vitamins and minerals on some biomarkers of aging, life span and spontaneous tumorigenesis has been studied in female SHR mice
In this paper for the first time it was shown that novel polyphenolic composition based on benzenepolycarboxylic acids (BP-C3) increases lifespan and alleviates spontaneous tumor development
Summary
BP-C3 is a composition jointly developed by N.N. Petrov Research Institute of Oncology and Nobel Ltd. [1] and comprising a novel polymer BP-Cx-1 (produced under the license from RD Innovation ApS, Denmark), iron complex, selenium, ascorbic acid and retinol. [1] and comprising a novel polymer BP-Cx-1 (produced under the license from RD Innovation ApS, Denmark), iron complex, selenium, ascorbic acid and retinol. BP-Cx-1 polymer, comprising benzenepolycarboxylic acids (polyphenolic compounds), produced from lignin and resembling structure of plant flavonoids, is used as a carrier-ligand in a novel anti-tumor platinum analogue BP-C1 [2] and in a novel radio-mitigator – BP-C2, containing molybdenum complex [3]. Ascorbic acid is reported to be able to eliminate this negative effect of polyphenolic compounds [7]. For these reasons, along with iron the composition was supplemented with ascorbic acid
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