Abstract

Abstract Background: Noncommunicable diseases in India are calculated to account for 63% of total mortality, and cancer is one of the principle causes up to 9% of total deaths. Objective: The objective of the study was t collect and analyze data about drugs taken by patients, which were prescribed by the doctor to combat side effects and to determine the extent of polypharmacy in patients on cancer chemotherapy Materials and Methods: A cross-sectional study in a Tertiary Care Hospital of Central India in the adult population by giving questionnaire forms to assess polypharmacy usage. Necessary statistical tests were applied. Results: A total of 40 indoor patients receiving cancer chemotherapy were included in the study. Many potential interactions between two chemotherapeutic drugs and chemotherapeutic and adjuvant drugs were studied. Positive adverse drug reactions encountered by patients had a strong correlation with these interactions. Conclusion: Drug interactions during chemotherapy are a common occurrence. The judicious use of cancer chemotherapeutic medicines and their combination with adjuvants are required to decrease the incidence of adverse drug reactions and increase the efficacy of chemotherapy.

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