Abstract
Several oligopeptides of the general formula A-Ly[graphic omitted].(or [graphic omitted]lu).Glyn.[graphic omitted]lu.(or [graphic omitted]ys).Glyn.OB have been synthesised; their projected use for polymerisation experiments and for “doubling” imposes limitations on the protecting groups which can be used, since these must be selectively removable. In two cases, it was not found possible to remove an N-formyl group without breaking peptide linkages, while in these and a further case, selective removal of other protecting groups was prevented by the great lability of side-chain benzyl ester groups towards alkali. Finally, four protected oligopeptides of the required type were synthesised, using benzyloxycarbonyl for α-N-protection, t-butyl ester for ω-C-protection, and trifluoroacetyl and methyl ester for the protection of lysine and glutamic acid side-chains, respectively. Three of these were converted into side-chain protected peptides suitable for polymerisation and into the free peptides, and two of them, by a “doubling” procedure into the octa- and dodeca-peptides.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of the Chemical Society. Perkin transactions 1
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
